A translation repressor element resides in the 3′ untranslated region of human p53 mRNA
Open Access
- 11 November 1999
- journal article
- research article
- Published by Springer Nature in Oncogene
- Vol. 18 (47), 6419-6424
- https://doi.org/10.1038/sj.onc.1203064
Abstract
The 3′ untranslated region of human p53 mRNA represses translation both in vitro and in vivo. Here, we identify a cis-acting 66-nucleotide U-rich sequence in the human p53 mRNA 3′ untranslated region that mediates translational repression. Using UV cross-linking, we detect a 40 kDa protein that interacts specifically with the p53 3′UTR containing the repressor element. Enhanced translation of p53 mRNA contributes to the accumulation of p53 protein in cells exposed to γ-radiation and could be a consequence of relieving the inhibition mediated by the repressor element.Keywords
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