ANTIBIOTICS AND CHEMOTHERAPEUTICS IN RENAL LYMPH - EXPERIMENTAL-STUDY IN DOGS

Abstract

Renal lymph concentrations of ampicillin, carbenicillin, cephacetrile, cephaloridine and nitrofurantoin were determined in a total of 28 dogs during constant infusion of the drugs together with [125I]iothalamate and [131I]o-iodohippurate for simultaneous determination of glomerular filtration rate and effective renal plasma flow. The lymph concentrations of the radiolabeled clearance substances, serving as a standard, were compared to those of the antimicrobial agents. The lymph concentrations of the 4 antibiotics were all significantly lower than the respective simultaneous arterial plasma concentrations. The nitrofurantoin lymph concentrations were equal to the simultaneous plasma concentrations. The renal lymph concentrations of antibiotics and chemotherapeutics apparently do not exceed the simultaneous plasma concentrations unless the urine flow is obstructed.