THE DIABETOGENIC EFFECT OF DIETHYLSTILBESTROLIN ADRENALECTOMIZED HYPOPHYSECTOMIZED-PARTIALLYDEPANCREATIZED RATS

Abstract

To test the hypothesis that the diabetogenic activity of diethylstilbestrol may be mediated through the ant. pituitary or the adrenal and pituitary glands together, hypophysec-tomized-adrenalectomized-partially depancreatized [male] rats were used as test animals. The animals were maintained on sub-diabetogenic amts. of adrenal cortical and ant. pituitary extracts. The adm. of diethylstilbestrol caused hyperglycemia and glycosuria in all of the test animals which were non-diabetic during the control periods. In those cases where the spontaneous glycosuria was mild it was intensified by the adm. of diethylstilbestrol, however, when the spontaneous glycosuria was moderate or severe the adm. of diethylstilbestrol failed to intensify it. Although, it was clearly demonstrated that diethylstilbestrol had some diabetogenic effect in the rat which was not mediated by either the adrenal or pituitary glands, its action was less marked than in similar animals having these 2 glands intact.