Studies on Experimental Chagas' Disease in Mice in Relation to Chemotherapeutic Testing

Abstract

Using a virulent strain of Trypanosoma cruzi which on intraperit. inoc. kills young female mice in an avg. of 21 days, estimates of drug activity could be based on median and mean survival time and percentage survival to 60 days thus obviating the need for time -consuming blood examinations to obtain quantitative comparisons.