Glucose and hexosediphosphate breakdown in tumour tissue

Abstract

Chopped tumour tissue formed acid in the Warburg manometer from both glucose and Na hexosediphosphate. The power to glycolyse hexosediphosphate was last on keeping the tissue for some hrs. in the ice-chest, but was restored by adding pyruvate. Pyruvate had no effect on glucose glycolysis under the same conditions. dl-Glyceraldehyde inhibited glucose glucol-ysis but had no effect on hexosediphosphate glycolysis. Then expts. showed that the routes of glucose breakdown and hexosediphosphate breakdown must be to some extent distinct. Glucose breakdown could proceed apparently without phosphorylation, as in embryonic tissue.