Toward Understanding Molecular Recognition between PRMTs and their Substrates
- 23 September 2020
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Current Protein & Peptide Science
- Vol. 21 (7), 713-724
- https://doi.org/10.2174/1389203721666200124143145
Abstract
Protein arginine methylation is a widespread eukaryotic posttranslational modification that occurs with as much frequency as ubiquitinylation. Yet how the nine different human protein arginine methyltransferases (PRMTs) recognize their respective protein targets is not well understood. This review summarizes the progress that has been made over the last decade or more to resolve this significant biochemical question. A multipronged approach involving structural biology, substrate profiling, bioorthogonal chemistry and proteomics is discussed.Keywords
Funding Information
- National Science Foundation (CHE- 1412405)
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