Effects of Repeated Bleedings on Serum Glycoprotein Concentrations in the Guinea Pig

Abstract

Effects of repeated bleedings on the serum concentrations of total glycoprotein, seromucoid, albumin polysaccharide, globulin polysaccharide, total protein, albumin and globulin and on the hematocrit and hemoglobin values of blood were investigated in adult male guinea pigs. Significant increases occurred in the seromucoid fraction and in the carbohydrate and protein moieties of the globulin fraction. Significant decreases occurred in albumin polysaccharide, hemoglobin and hematocrit values. Statistical comparisons of the final values of the experimental group with those of a control group subjected to the same experimental procedures but without major blood loss were significant for total protein, albumin, hemoglobin and hematocrit. The conclusion was drawn that the alterations which occurred in the serum glycoprotein concentrations were not due primarily to blood loss.