Biology of CD34+CD38-Cells in Lymphohematopoiesis
- 1 January 1998
- journal article
- research article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 31 (3-4), 285-293
- https://doi.org/10.3109/10428199809059221
Abstract
Since the discovery of the CD34 stem/progenitor cell antigen, considerable progress has been made in further purifying human lymphohematopoietic stem cells (HSC). These studies have identified a number of antigens which can be targeted to subfractionate the CD34+ cell population. In particular, several lines of evidence suggest that the rare CD38- subpopulation of CD34+ cells may be enriched in HSC. This review briefly summarizes relevant knowledge concerning the CD38 molecule and the results of in vitro and in vivo studies of CD34+38- cells. Possible clinical uses for purified CD34+38” cells are outlined.Keywords
This publication has 56 references indexed in Scilit:
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNature Medicine, 1997
- CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype.The Journal of Experimental Medicine, 1996
- CD38 ligation induces discrete cytokine mRNA expression in human cultured lymphocytesEuropean Journal of Immunology, 1995
- CD38 signaling by agonistic monoclonal antibody prevents apoptosis of human germinal center B cellsEuropean Journal of Immunology, 1994
- A cell initiating human acute myeloid leukaemia after transplantation into SCID miceNature, 1994
- Gene transfer into hematopoietic progenitor and stem cells: Progress and problemsThe International Journal of Cell Cloning, 1994
- Human lymphocyte antigen CD38 catalyzes the production of cyclic ADP‐riboseFEBS Letters, 1993
- A Single Protein Immunologically Identified as CD38 Displays NAD+ Glycohydrolase, ADP-Ribosyl Cyclase and Cyclic ADP-Ribose Hydrolase Activities at the Outer Surface of Human ErythrocytesBiochemical and Biophysical Research Communications, 1993
- Expression of Thy-1 on human hematopoietic progenitor cells.The Journal of Experimental Medicine, 1993
- Purification and Characterization of Mouse Hematopoietic Stem CellsScience, 1988