Erythrocyte Repopulation in X-Irradiated Recipients of Nucleated, Peripheral Blood Cells of Normal Mice

Abstract

Strains of mice are being produced that are isogenic with inbred stocks except for the hemoglobin locus. With mice of such strains, experiments were carried out to ascertain whether peripheral blood of normal mice contains cells capable of repopulating the marrow of irradiated recipients. In 3 of 5 recipients injected intravenously with 100 million nucleated peripheral blood cells after 600 r, increasing numbers of graft-derived erythro-cytes were noted within 60 days after treatment, indicating the pres-ence in peripheral blood of cells that are able to give rise to mature erythrocytes.