The road to modularity
Top Cited Papers
- 1 December 2007
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 8 (12), 921-931
- https://doi.org/10.1038/nrg2267
Abstract
A network of interactions is called modular if it is subdivided into relatively autonomous, internally highly connected components. Modularity has emerged as a rallying point for research in developmental and evolutionary biology (and specifically evo-devo), as well as in molecular systems biology. Here we review the evidence for modularity and models about its origin. Although there is an emerging agreement that organisms have a modular organization, the main open problem is the question of whether modules arise through the action of natural selection or because of biased mutational mechanisms.Keywords
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