Growth Failure, Somatomedin and Growth Hormone Levels in Juvenile Diabetes Mellitus-A Pilot Study
- 1 June 1979
- journal article
- research article
- Published by Wiley in Australian and New Zealand Journal of Medicine
- Vol. 9 (3), 245-249
- https://doi.org/10.1111/j.1445-5994.1979.tb04131.x
Abstract
Growth hormone (hGH) responsiveness to exercise and somatomedin C (SmC) activity were measured in 10 children with insulin-deficient diabetes mellitus. Four of the 10 children showed a significant degree of growth retardation. Normal SmC activity was found in association with elevated hGH levels. The hypothesis that growth-retarded diabetics have a failure of Sm production despite high hGH levels (analogous to malnutrition and Laron dwarfism) was not substantiated by this study. Chronic deficiency of insulin, itself a somatomedin, may play a major role in diabetic growth failure.Keywords
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