Response of human and canine gall bladder to cholecystokinin

Abstract

A sterile, non-antigenic and pyrogen-free cholecystokinin (CCK) concentrate isolated from hog duodenums was injd. intraven. into 8 normal human males after visualization of the respective gall bladders under X-ray. 5 of the above were reinjd. with the same or higher dosage 6 mos. later. With the exception of 3, all showed definite contraction with 66 or 150 U. of CCK; complete emptying occurred in one (66 U.). Side reactions to the injn. developed in one subject with a seasonal allergic asthma who displayed a very small gall bladder contraction. Although CCK in dosages of 18 and 66 U. was ineffective in one case, definite contraction of the viscus ensued with 150 U. Admn. of varied single dosages (and in some cases, serial injns.) of CCK concentrates in a number of dogs, parallelled the human studies.