Phorbol ester inhibition of vasopressin-induced calcium efflux from cultured rat aortic myocytes
- 15 September 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 205 (2), 251-254
- https://doi.org/10.1016/0014-5793(86)80907-3
Abstract
The effect of the protein kinase C activator TPA was investigated on AVP-induced 45Ca release from rat aortic myocytes. In the nanomolar range TPA, but not 4β-phorbol, reduced the brief 45Ca efflux produced by AVP in the presence or in the absence of extracellular calcium. The maximal effect of TPA was to abolish the response to a half maximally active concentration of AVP, and to reduce by 50% the maximal response to the hormone. These results suggest that protein kinase C activation can exert a negative control on the early AVP-induced calcium mobilization in vascular smooth muscleKeywords
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