Biosynthesis of glutathione by rat erythrocytes

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Abstract
The existence in rat erythrocytes of an enzyme system capable of conjugating the constituent amino acids to form glutathione has been shown. An absolute requirement for Mg and K ions for glutathione formation is indicated. Addition of adenosine or of adenosine 5[image]-monophosphate has a favorable effect on the synthesis. The effects of dietary folic acid and vitamin B12 deficiencies on synthesis of glutathione in vitro have been studied. Folic acid has little effect whereas vitamin B12 deficiency causes a decrease in glutathione synthesis by erythrocytes although there is interference due to hemolysis under this condition.