Aryl−CF3 Bond-Forming Reductive Elimination from Palladium(IV)
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- 15 February 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 132 (9), 2878-2879
- https://doi.org/10.1021/ja100955x
Abstract
This communication describes oxidatively induced Ar−CF3 bond-forming reductive elimination from new PdII complexes of general structure (L∼L)PdII(Ar)(CF3). The electrophilic fluorinating reagent N-fluoro-2,4,6-trimethylpyridinium triflate promotes these reactions in good to excellent yields. The palladium(IV) intermediate (tBu-bpy)PdIV(CF3)(F)(OTf)(C6H4F) has been isolated, characterized, and demonstrated to undergo high yielding Ar−CF3 coupling upon thermolysis. This work provides an attractive conceptual framework for the development of PdII/IV-catalyzed arene trifluoromethylation reactions.Keywords
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