Leukocyte Alkaline Phosphatase Activity in Rickets Due to Vitamin D Deficiency

Abstract

LEUKOCYTE alkaline phosphatase (LAP) activity has been assayed under different hematologic and clinical conditions,^{1 2 3 4} but has generally been used to differentiate chronic myelocytic leukemia from severe leukemoid reactions.^{5 , 6} Recently, however, studies on LAP activity have been performed from the genetic standpoint and as a possible chromosome marker.^{7 8 9 10 11} The rise of serum alkaline phosphatase is a characteristic finding in rickets along with the decrease of serum phosphorus level. The type of isoenzyme in the serum in this condition has also been determined, but tissue alkaline phosphatase has not been investigated.¹² In this study, the LAP levels were measured in patients with . . .