Expression of Hel‐N1 and HeL‐N2 in small‐cell lung carcinoma
- 1 May 1996
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 39 (5), 679-681
- https://doi.org/10.1002/ana.410390520
Abstract
Hel-Nl and HuD are neuron-specific RNA-binding proteins that are antigenic targets of anti-Hu antibodies. Although expression of Hu antigens is most commonly seen in small-cell lung carcinoma, their exact identity (e.g., Hel-N1, HeLN2, HuD, and HuC) cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinctian. Here we demonstrate that Hel-Nl and Hel-N2 are expressed in small-cell lung carcinoma using reverse transcription-polymerase chain reaction.Keywords
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