Leg Patterning Driven by Proximal-Distal Interactions and EGFR Signaling
- 12 July 2002
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 297 (5579), 256-259
- https://doi.org/10.1126/science.1072311
Abstract
wingless and decapentaplegicsignaling establishes the proximal-distal axis of Drosophilalegs by activating the expression of genes such asDistalless and dachshund in broad proximal-distal domains during early leg development. However, here we show thatwingless and decapentaplegic are not required throughout all of proximal-distal development. The tarsus, which has been proposed to be an ancestral structure, is instead defined by the activity of Distalless, dachshund, and a distal gradient of epidermal growth factor receptor (EGFR)–Ras signaling. Our results uncover a mechanism for appendage patterning directed by genes expressed in proximal-distal domains and possibly conserved in other arthropods and vertebrates.Keywords
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