Edoxaban affects TRAP-dependent platelet aggregation
- 1 May 2020
- journal article
- research article
- Published by Springer Nature in Journal of Thrombosis and Thrombolysis
- Vol. 49 (4), 578-583
- https://doi.org/10.1007/s11239-020-02093-9
Abstract
Edoxaban is an oral anticoagulant drug and a direct factor Xa inhibitor. However, it is still not fully understood if and how edoxaban impacts platelet function. This prospective study aimed to assess in vitro platelet function in patients with atrial fibrillation (AF) receiving edoxaban. It was a single centre study quantifying platelet aggregation in 20 patients treated with edoxaban by light transmission aggregometry. The thrombin receptor activating peptide (TRAP)-induced platelet aggregation was significantly lower 2 h after taking edoxaban compared to baseline value (44.7 +/- 32.03% vs. 73.3 +/- 25.55%; p < 0.0001). In addition, we did not find any significant difference in results between the patient groups. The TRAP-induced platelet aggregation is reduced in non-valvular AF patients receiving edoxaban.Keywords
Funding Information
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV (VEGA 1/0187/17)
- Agentúra na Podporu Výskumu a Vývoja (APVV-17-0054)
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