THE ALLOANTIBODY RESPONSE TO SEMIALLOGENEIC PREGNANCY IN THE RAT
- 31 August 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 46 (3), 413-417
- https://doi.org/10.1097/00007890-198809000-00017
Abstract
Evidence for a unique class I MHC antigen (termed Pa), which is believed to be expressed on rat trophoblast during pregnancy and which stimulates alloantibody formation with unusual interstrain cross-reactivity, has been examined in inbred rats. The previously reported pattern of crossreactivity was confirmed but was not unique to antisera produced by pregnancy. Antibody blocking studies using biotinylated rat monoclonal antibodies to distinct epitopes on RTIAa antigens suggested that antibodies present in pregnancy sera, especially from multiparous rats, reacted with several epitopes on these molecules. Moreover, a rat monoclonal antibody, 381–1E10, directed against the putative Pa epitope was shown by synergistic lysis and cold antibody competition to be directed to the immunodominant S epitope on RTIAa. These data argue against the existence of a distinct Pa antigen or epitope detected by pregnancy sera.Keywords
This publication has 14 references indexed in Scilit:
- Prolonged Survival of Rat Renal Allografts after Multiple Allogeneic Pregnancies: Strain Specificity and role of Erythrocyte Antibody Rosette Inhibiting AntibodiesClinical Science, 1985
- PREGNANCY-INDUCED MONOCLONAL ANTIBODY TO A UNIQUE FETAL ANTIGENTransplantation, 1984
- ELICITATION OF THE MATERNAL ANTIBODY RESPONSE TO THE FETUS BY A BROADLY SHARED MHC CLASS I ANTIGENIC DETERMINANTTransplantation, 1984
- The alloantigenic organization of RT1Aa, a class I major histocompatibility complex molecule of the ratEuropean Journal of Immunology, 1984
- The mechanism of synergistic complement‐mediated lysis of rat red cells by monoclonal IgG antibodiesEuropean Journal of Immunology, 1983
- The alloantibody response in the allogeneically pregnant rat. II. Primary pregnancy-induced anti-RT1Aa alloantibodies are not as cross-reactive as secondary pregnancy-induced or conventionally raised alloantibodies.The Journal of Immunology, 1982
- Immune response genes controlling responsiveness to major transplantation antigens. Specific major histocompatibility complex-linked defect for antibody responses to class I alloantigens.The Journal of Experimental Medicine, 1982
- The adoptive transfer of pregnancy-induced unresponsiveness to male skin grafts with thymus-dependent cells.The Journal of Experimental Medicine, 1977
- IMMUNE RESPONSE ENGENDERED IN MICE BY MULTIPARITYTransplantation, 1964
- Specific Homograft Tolerance Induced by Successive Matings and Implications Concerning Choriocarcinoma2JNCI Journal of the National Cancer Institute, 1960