GLYCOSYLATED HEMOGLOBIN AND PROTEIN-LEVELS IN NORMAL AND DIABETIC PREGNANCIES - RELATION TO BIRTH-WEIGHT
- 1 April 1986
- journal article
- research article
- Vol. 67 (4), 533-536
Abstract
Glycosylated hemoglobin and protein were measured in maternal and cord blood of 24 normal, 19 class A, and ten insulin-treated diabetics using an affinity chromatographic technique. Maternal (intrapartum) glycohemoglobin and glycoprotein levels in the diabetics were not significantly different from those in normal controls, suggesting "tight" metabolic control in these patients. Compared with controls, cord blood glycohemoglobin and glycoprotein levels were significantly higher in insulin-treated, but not in class A, diabetics. The birth weight ratio correlated significantly only with maternal glycohemoglobin in insulin-treated diabetics. The results suggest that: (1) even in well-controlled insulin-treated diabetics, the fetuses are hyperglycemic; (2) maternal glycohemoglobin correlates with birth weight in insulin-treated diabetics; (3) maternal glycoprotein determinations cannot be used to predict birth weight; (4) hyperglycemia cannot be the sole determinant of fetal overgrowth in diabetic pregnancies; (5) factors influencing fetal overgrowth in class A and insulin-treated diabetics may be different.This publication has 9 references indexed in Scilit:
- Glycosylated Hemoglobin and Plasma Protein in Newborns of Normal and Diabetic WomenPediatric Research, 1984
- Affinity Chromatographic Quantitation of Glycosylated Hemoglobin in Newborn InfantsHemoglobin, 1983
- Determination of glycosylated hemoglobin by affinity chromatography: comparison with colorimetric and ion-exchange methods, and effects of common interferences.Clinical Chemistry, 1982
- Minor (glycosylated) hemoglobins in cord blood of infants of normal and diabetic mothersAmerican Journal of Obstetrics and Gynecology, 1981
- Hemoglobin A1c in normal and diabetic pregnancyJAMA, 1979
- Glycosylated hemoglobins and diabetes mellitus in pregnancyAmerican Journal of Obstetrics and Gynecology, 1979
- GLYCOSYLATED HEMOGLOBINS IN NORMAL-PREGNANCY AND GESTATIONAL DIABETES-MELLITUS1979
- The Glycosylation of Hemoglobin: Relevance to Diabetes MellitusScience, 1978
- Glycohemoglobin (HbAIc): A predictor of birth weight in infants of diabetic mothersThe Journal of Pediatrics, 1978