Modification of theophylline-induced lipolysis in human fat cells after trypsination

Abstract
Trypsin-treatment of human fat cells results in the potentiation of the lipolytic response and the cAMP accumulation induced by theophylline (5·10−4 M) but not of those induced by theophylline (5·10−3 M). The amount of cAMP formed after exposure to theophylline (5·10−3 M) plus norepinephrine (5·10−6 M) remains, however, 2.6fold higher in trypsin-treated human fat cells than in the control ones.