Connective Tissue IV. Effect of Age upon Dermal Chemical Response to Adrenal Hormones.

Abstract

Both Cortisol and Doca similarly affect the chemistry of the connective tissue in that they result in a decrease in total and insoluble collagen concentration of rat skin. The effects of these hormones upon rat skin are profoundly altered by the age of the animal. The aged rat demonstrates a considerably different dermal chemical response to Cortisol and particularly Doca than does either the young or the mature animal.