The intracellular phosphorylation of (−)-2′-deoxy-3′-thiacytidine (3TC) and the incorporation of 3TC 5′-monophosphate into DNA by HIV-1 reverse transcriptase and human DNA polymerase γ
- 28 September 1995
- journal article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 50 (7), 1043-1051
- https://doi.org/10.1016/0006-2952(95)96620-a
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gammaAntimicrobial Agents and Chemotherapy, 1992
- Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.Published by Elsevier ,1992
- Cellular metabolism of (−) enantiomeric 2′-deoxy-3′-thiacytidineBiochemical Pharmacology, 1992
- Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporationBiochemistry, 1992
- (-)-2'-deoxy-3'-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitroAntimicrobial Agents and Chemotherapy, 1992
- Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria.Journal of Clinical Investigation, 1992
- The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitroAntimicrobial Agents and Chemotherapy, 1992
- Factors contributing to the inhibition of HIV reverse transcriptase by chain‐terminating nucleotides in vitro and in vivoFEBS Letters, 1991
- Exonucleolytic proofreading by a mammalian DNA polymerase .gamma.Biochemistry, 1989
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology, 1973