FUNCTIONAL-DIFFERENTIATION OF T-CELL PRECURSORS .1. PARAMETERS OF CARRIER-SPECIFIC TOLERANCE IN MURINE HELPER T-CELL PRECURSORS
- 1 January 1979
- journal article
- research article
- Vol. 123 (5), 2083-2087
Abstract
Irradiated mice reconstituted with bone marrow from sheep .gamma.-globulin-(SGG) tolerant syngeneic donors display reduced Ig[immunoglobulin]G responsiveness to challenge with trinitrophenylated (TNP)-SGG compared with recipients of normal marrow. This effect is SGG-specific and is not due to suppressor T [thymus-derived] cells or to antigen carryover. Helper T cell precursor tolerance can be induced with as little as 40 .mu.g tolerogen (SGG). Unlike mature helper T cells, these precursors show a rapid induction and rapid waning patterns, suggesting a high rate of turnover. Apparently marrow helper T cell precursors bear antigen-specific receptors and the T cell repertoire must be at least partially generated before residence in the thymus.This publication has 5 references indexed in Scilit:
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