A remotely programmable insulin delivery system. Successful short-term implantation in man
- 2 April 1982
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 247 (13), 1848-1853
- https://doi.org/10.1001/jama.247.13.1848
Abstract
A remotely controlled, programmable insulin delivery system was implanted in a diabetic man and the feasibility of the technique was examined. Specific problems included the following: development of an appropriate surgical approach, identification of methods to assess the integrity of the insulin delivery system following implantation, and assessment of plasma glucose and free-insulin profiles obtained with the implanted system. The insulin pump was implanted submuscularly through a midline abdominal incision. The insulin reservoir was placed subcutaneously to allow percutaneous refilling. The insulin delivery catheter terminated in the peritoneal space. No postoperative wound infection occurred and rapid healing of the surgical site ensued. In vivo assessment of the system included dye contrast roentgenography, vasopressin stimulation and reservoir volume monitoring. Short-acting insulin was then placed in the implanted reservoir and delivered by the system for 1 mo. Mean plasma glucose concentration declined to normal levels, as did glycosylated Hb. Plasma insulin profiles were normalized with appropriate insulin peaks with each meal. Implantation of a remotely programmable insulin pump is feasible in type I diabetic man. Additional studies are necessary to define which patients will benefit from this type of insulin delivery system.This publication has 8 references indexed in Scilit:
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