In vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods
- 28 October 2008
- journal article
- Published by Optica Publishing Group in Optics Express
- Vol. 16 (23), 18605-18615
- https://doi.org/10.1364/oe.16.018605
Abstract
The use of gold nanorods for photoacoustic molecular imaging with simultaneous multiple targeting is reported. Multiple targeting is done by utilizing the tunable optical absorption property of gold nanorods. This technique allows multiple molecular signatures to be obtained by simply switching laser wavelength. HER2 and EGFR were chosen as the primary target molecules for examining two cancer cells, OECM1 and Cal27. Both in vitro and in vivo mouse model imaging experiments were performed, with contrast enhancement of up to 10dB and 3.5dB, respectively. The potential in improving cancer diagnosis is demonstrated.Keywords
This publication has 19 references indexed in Scilit:
- Photoacoustic Imaging of Multiple Targets Using Gold NanorodsIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2007
- Photoacoustic flow measurements based on wash-in analysis of gold nanorodsIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2007
- In vivo cancer targeting and imaging with semiconductor quantum dotsNature Biotechnology, 2004
- Molecular imaging of gene therapy for cancerGene Therapy, 2004
- In vivomolecular and genomic imaging: new challenges for imaging physicsPhysics in Medicine & Biology, 2004
- Imaging Tumor Angiogenesis With Contrast Ultrasound and Microbubbles Targeted to α v β 3Circulation, 2003
- Photoacoustic measurement of epidermal melaninPublished by SPIE-Intl Soc Optical Eng ,2003
- Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility studyApplied Optics, 2002
- Near-Infrared Fluorescent Nanoparticles as Combined MR/Optical Imaging ProbesBioconjugate Chemistry, 2002
- Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumorsIEEE Journal of Selected Topics in Quantum Electronics, 1999