Hepatotoxicity Due to Treatment with Papaverine
- 11 December 1969
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 281 (24), 1333-1335
- https://doi.org/10.1056/nejm196912112812404
Abstract
Hepatotoxicity due to papaverine was observed in four patients. A cause and effect relation was demonstrated by repeated rechallenge with the drug. The patients had abdominal discomfort, but jaundice was not prominent. Serum alkaline phosphatase and transaminases were elevated. Liver biopsies in Cases 2 and 3 showed numerous eosinophils in the periportal spaces. Both symptoms and signs appeared to be fully reversible. The most likely mechanism is a hypersensitivity reaction.Keywords
This publication has 2 references indexed in Scilit:
- Papaverine in the Treatment of Coronary-Artery DiseaseNew England Journal of Medicine, 1945
- SOME CLINICAL USES OF PAPAVERINE IN HEART DISEASEPublished by American Medical Association (AMA) ,1942