METABOLISM OF ORGANOPHOSPHORUS INSECTICIDES: III. FATE OF THE METHYL GROUPS OF DIPTEREX IN VIVO
- 1 August 1965
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 43 (8), 1271-1275
- https://doi.org/10.1139/o65-140
Abstract
Direct evidence for the hydrolysis of O-methyl ester linkage(s) of Dipterex in the rat has been obtained using Dipterex in which the two methyl groups are C14-labelled. Following a single injection (i.p.) of radio-Dipterex, about 60% of the C14activity was recovered, after 24 hours, in the expired air and in the urine. C14O2and C14-formate constituted about 50% of the recovered radioactivity. The contribution of P—OCH3cleavage to the detoxification of the insecticide has been discussed. A scheme for the fate of the methyl groups has been suggested.This publication has 9 references indexed in Scilit:
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