The rate equation and activation energies for the uptake of α-aminoisobutyric acid by mouse brain slices

Abstract

1. The initial influx of the amino acid analogue AIB at medium concentrations of 0·05-20 mM into mouse cerebrum slices incubated at temperatures from 20 to 45° C follows the rate law v = Vmax/(1 + Kt/S)+kuS. The linear term kuS arises from an unsaturable process of concentrative uptake.