Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 51 (2), 181-183
- https://doi.org/10.1007/bf00431737
Abstract
Cis (α)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (β)-flupenthixol and (-)-butaclamol are not. α-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the β-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.This publication has 20 references indexed in Scilit:
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