Experimental Hypertensions Treated with CG14: Measurements of Adrenal Function, Vascular Responsiveness, Angiotensinase and Converting Enzyme.

Abstract

Summary During restoration of normotension by giving CCI₄ to experimental renal and post-DCA hypertensive rats, serum incubated with renin yields predominantly angiotensin I. This suggests a deficit in hepatogenous converting enzyme. However, incubation of post-CC1₄ normotensive serum with normal serum containing this enzyme still yielded angio-tensins I and II. This suggests that CCI⁴ liver injury is associated with formation of a substance that inhibits circulating converting enzyme. Adrenal failure, angiotensinase excess and decreased pressor responsiveness to angiotensin do not participate in the pressure lowering effect of CCI₄.