The Effects of Hemoglobin Solutions on Renal Functions in Man
Open Access
- 1 November 1951
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 6 (11), 1152-1158
- https://doi.org/10.1182/blood.v6.11.1152.1152
Abstract
Solns. of hemoglobin containing dextrose, nicotinic acid and amide, ammonia, and hexose diphosphate increased the glomerular filtration rate in 1/3 of the cases, and decreased it in the others. There was a marked fall in the effective plasma flow, urinary output and sodium excretion in all cases. Although nephrotoxic, intraven. doses of 8-30 g. hemoglobin provoked no irreversible renal injury in 14 subjects with normal or elevated diastolic pressures and urine flows.Keywords
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