Oral Administration of a Potent Carbonic Anhydrase Inhibitor (Diamox)

Abstract

IN a preceding paper¹ the metabolic effects of a new potent carbonic anhydrase inhibitor ("Diamox") were reported. In patients with congestive heart failure oral administration of this compound regularly resulted in excretion of an alkaline urine containing increased amounts of potassium and sometimes increased quantities of sodium.The present study was undertaken to evaluate the clinical efficacy of Diamox as a diuretic in patients with severe congestive heart failure. The action of the drug in patients with respiratory acidosis and congestive heart failure due to chronic cor pulmonale is the subject of another report.² Methods and MaterialsTwenty-six patients with . . .