Chromosomal Translocations in Ewing's Sarcoma
- 25 August 1983
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 309 (8), 496-498
- https://doi.org/10.1056/nejm198308253090817
Abstract
To the Editor: We performed a cytogenetic analysis in four cases of Ewing's tumor. All metaphases were obtained after two-day cultures of fresh tumor cells. RHG- and THA-banded chromosomes1 , 2 were analyzed, and the structural rearrangements were classified according to the international nomenclature.3 In all four cases clones with abnormalities were observed, and no cells with normal karyotype could be found. In all the cells, we observed reciprocal translocations involving band ql2 of chromosome 22 (Fig. 1): in Case 1, t(2;22;ll)(p22;ql2;?); in Case 2, t(9;22;20)(q34;ql2;pl2); in Case 3, t(l1;22)(q24;ql2); and in Case 4, t(ll;22)(q24;ql2) and t(l;22)(p21;ql2).Additional chromosomal abnormalities were observed . . .Keywords
This publication has 7 references indexed in Scilit:
- Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.Proceedings of the National Academy of Sciences, 1982
- Chromosomal Localization of the Human Homolog (c- sis ) of the Simian Sarcoma Virus onc GeneScience, 1982
- Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells.Proceedings of the National Academy of Sciences, 1982
- An International System for Human Cytogenetic Nomenclature — High-Resolution Banding (1981): ISCN (1981)Cytogenetic and Genome Research, 1981
- A simple method for R banding of human chromosomes, showing a pH-dependent connection between R and G bandsHuman Genetics, 1974
- Nouveau système de marquage chromosomique: les bandes TChromosoma, 1973
- A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMESThe Lancet, 1971