THE BILIARY EXCRETION OF SULFOBROMOPHTHALEIN SODIUM (BSP) IN THE RAT AS A CONJUGATE OF GLYCINE AND GLUTAMIC ACID *†
Open Access
- 1 August 1959
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 38 (8), 1426-1433
- https://doi.org/10.1172/jci103919
Abstract
An analysis of sulfobromophthalein sodium (BSP) compounds appearing in rat bile after intravenous administration reveals 4 distinct bands by filter paper chromatography, one of which migrated with the same Rf as standard BSP. The major band, designated BSP-A, accounted for 50 to 80% of the excreted BSP when graded doses of this dye were administered. Hydrolysis of BSP-A yielded BSP and 2 ninhydrin spots which were identified as glycine and glutamic acid. No evidence of a glucuronic acid conjugate was found.Keywords
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