Renal clearances of oxypurinol and inulin on an isocaloric, low-protein diet
- 1 June 1988
- journal article
- research article
- Published by Springer Nature in Clinical Pharmacology & Therapeutics
- Vol. 43 (6), 681-687
- https://doi.org/10.1038/clpt.1988.95
Abstract
In previous studies a low-calorie, low-protein diet caused a sustained reduction in both oxypurinol and uric acid renal clearances (CLR). With the hypothesis that the decrease in CLR was due to the low-protein and not the low-caloric content of the diet, we studied the CLR of oxypurinol, uric acid, creatinine, and inulin in normal subjects during isocaloric (2600 calories per 70 kg per day), normal-protein (150 gm per day), and low-protein (19 gm per day) diets. There were three major findings: (1) the CLR of oxypurinol declined from 26.6 .+-. 1.8 ml/min on the normal-protein diet to 13.5 .+-. 1.4 ml/min on the isocaloric low-protein diet (P < 0.05); (2) the CLR of inulin and creatinine fell 14% and 20%, respectively, on the low-protein diet compared with the normal-protein diet (both P < 0.05); and (3) there was a diurnal variation in the CLR of oxypurinol. We conclude that the decreased CLR of oxypurinol was the result of the reduced protein content of the diet and the CLR of both inulin and creatinine were decreased on the low-protein diet.This publication has 9 references indexed in Scilit:
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