Prostaglandins E 1 and E 2 Antagonize Norepinephrine Effects on Cerebellar Purkinje Cells: Microelectrophoretic Study
- 12 December 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3911), 1418-1420
- https://doi.org/10.1126/science.166.3911.1418
Abstract
In microelectrophoretic experiments, prostaglandins E1 and E2 antagonize the reduction in discharge rate of cerebellar Purkinje cells produced by norepinephrine. Slowing of discharge evoked by 3',5'-adenosine monophosphate or gamma aminobutyric acid is not antagonized. These data provide the first indication that endogenous prostaglandins may physiologically function to modulate central noradrenergic junctions.Keywords
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