Alkali-Resistant Hemoglobin in Aplastic Anemia of Both Acquired and Congenital Types
- 18 January 1962
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 266 (3), 117-120
- https://doi.org/10.1056/nejm196201182660303
Abstract
DURING a study of patients with aplastic anemia1 it was noted that blood from such patients showed an increased amount of alkali-resistant hemoglobin. It is known that increased production of alkali-resistant or fetal hemoglobin is usually associated with some genetically determined anemias such as thalassemia and sickle-cell anemia. Scattered reports have also indicated that production of fetal hemoglobin may be reactivated in some acquired disorders such as pernicious anemia, multiple myeloma,2 molar pregnancy3 and aplastic anemia.2 , 4 , 5 The evaluation of alkali-resistant hemoglobin in this last condition, however, has yielded conflicting results. Although some investigators have found abnormal amounts of this hemoglobin . . .Keywords
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