INFLUENCE OF DIETARY FACTORS ON CERTAIN BLOOD PARAMETERS AND THE PRODUCTION OF ENDOTOXIN-INITIATED PHLEBOTHROMBOSIS IN RAT

Abstract

Provided rats were fed lipid-rich low-protein diets containing sodium cholate, a high incidence of large hepatic vein thrombosis could be initiated by the injection of E. coli or S. typhosa lipopolysaccharides. Although hyperlipemia seemed to be a necessary prerequisite for the induction of these phlebothromboses, no definite relationship could be found between the tendency to thrombosis and the level of glucose, uric acid, cholesterol, and triglycerides in the serum. The value of the percentage of alpha-lipoproteins in this respect awaits further confirmation.In contrast to the thrombotic tendency, the susceptibility to shock seems to have some connection with the serum cholesterol and more certainly with the triglyceride levels. The more saturated the dietary fats utilized, the higher were the triglycerides in the serum, and the more susceptible were the animals to shock, but not to thrombosis.