Studies on the Pathogenesis of Experimental Necrotizing Arteritis.

Abstract

Previous studies have shown that the combination of "standard high fat diet" plus "standard renal damage" resulted in typical arterial lesions in 36 of 40 dogs (90%). The data presented in the present report indicate that "standard high fat diet" plus damage to organs and tissues other than the kidney (chloroform injury to the liver, turpentine abscesses of subcutaneum, and bacterial infections) failed to produce arterial lesions, and "standard high fat diet" plus renal insufficiency produced by bilateral ureteral ligation. also failed to produce arterial lesions. These studies emphasize the importance of the kidney in the pathogenesis of necrotizing arteritis and indicate that azotemia per se is not the "renal factor." They suggest the possibility that the epithelium of the proximal convoluted tubules elaborates one or more substances necessary for the proper utilization of certain lipid substances.