Influence of NOS1 on Verbal Intelligence and Working Memory in Both Patients With Schizophrenia and Healthy Control Subjects

Abstract

Schizophrenia (SZ) is a disorder of substantial heritability (approximately 80%) but uncertain underlying pathophysiology.¹ Despite some progress, most of the variance in SZ susceptibility attributable to genetic factors remains to be identified.² A number of recent studies using high-throughput technologies investigating structural and genomic sequence variation in large SZ samples have identified more consistent support for several susceptibility loci.^3-5 As genomic data emerge, important questions are how these variants increase disease liability and whether they are relevant to only the neurobiology of SZ or to neurodevelopment more generally.^6,7