Influence of NOS1 on Verbal Intelligence and Working Memory in Both Patients With Schizophrenia and Healthy Control Subjects
Open Access
- 1 October 2009
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 66 (10), 1045-1054
- https://doi.org/10.1001/archgenpsychiatry.2009.139
Abstract
Schizophrenia (SZ) is a disorder of substantial heritability (approximately 80%) but uncertain underlying pathophysiology.1 Despite some progress, most of the variance in SZ susceptibility attributable to genetic factors remains to be identified.2 A number of recent studies using high-throughput technologies investigating structural and genomic sequence variation in large SZ samples have identified more consistent support for several susceptibility loci.3-5 As genomic data emerge, important questions are how these variants increase disease liability and whether they are relevant to only the neurobiology of SZ or to neurodevelopment more generally.6,7Keywords
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