Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration “in vivo” by indirect mechanisms
- 1 June 1990
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 30 (3-4), 344-349
- https://doi.org/10.1007/bf01966298
Abstract
The α and β forms of recombinant interleukin-1 (IL-1α and IL-1β) and of recombinant Tumor Necrosis Factor (TNFα and TNFβ) induced dose-dependent neutrophil migration into rat peritoneal cavities. Migration induced by both IL-1s showed a bell-shaped dose-response curve and IL-1β was 3-fold more potent than IL-1α. Pretreatment of the animals with dexamethasone or depletion of the peritoneal macrophage population, abolished the neutrophil migration induced by the four cytokines. “In vitro” stimulation of macrophage monolayers with IL-1β and the TNFs released a factor into the supernatant which, unlike these cytokines, induced neutrophil migration in dexamethasone pretreated animals. These results suggest that the neutrophil migration induced by IL-1α, IL-1β and TNFβ is not due to a direct effect on neutrophils, but occurs via the release of a chemotactic factors(s) from resident macrophages.Keywords
This publication has 32 references indexed in Scilit:
- Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogueNature, 1988
- Neutrophil migration induced by inflammatory stimuli is reduced by macrophage depletionInflammation Research, 1988
- Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.The Journal of Experimental Medicine, 1988
- Recombinant human tumor necrosis factor α lacks chemotactic activity for human peripheral blood neutrophils and monocytesBiochemical and Biophysical Research Communications, 1988
- Biology and pharmacology of recombinant human interleukin-1β-induced rat ear inflammationInflammation Research, 1987
- Chemotactic activity of recombinant human interleukin-1Inflammation Research, 1987
- Secretory products of macrophages.JCI Insight, 1987
- Interleukin-1 and the Pathogenesis of the Acute-Phase ResponseNew England Journal of Medicine, 1984
- Are macrophages the body's alarm cells?Inflammation Research, 1980
- Anti-inflammatory activity of bacterial endotoxinJournal of Pharmacy and Pharmacology, 1977