G-CSF: Its relationship to leukemia differentiation-inducing activity and other hemopoietic regulators
- 1 January 1982
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 113 (S1), 53-64
- https://doi.org/10.1002/jcp.1041130411
Abstract
The murine myelomonocytic leukemia WEHI-3B exists as differentiation-inducible (D+) and noninducible (D−) cell lines. Both lines produce a CSF species that stimulates exclusively the formation of neutrophil granulocyte colonies. This G-CSF copurifies with a mast cell growth factor but can be separated from M- and GM-CSF. NZB bone marrow is unresponsive to G-CSF stimulation. WEHI-3B D+ cells can be induced to terminal granulocyte differentiation by a factor present in murine and human postendotoxin serum that is different from G-CSF present in WEHI-3B D+ or D− CM since the latter has little or no leukemia differentiation-inducing activity. Endotoxin treatment of C. parvum primed mice leads to simultaneous induction of serum activities with selective action on myeloid leukemic cells, a serum differentiation inducing activity and a leukemic colony inhibitory activity. These factors act synergistically to block leukemic stem cell self-renewal. The results suggest that a variety of inducible factors may have potent and selective antileukemic activity.Keywords
This publication has 27 references indexed in Scilit:
- Induction by Phorbol Esters of Macrophage Differentiation in Human Leukaemia Cell Lines does not Require Cell DivisionBritish Journal of Haematology, 1981
- Regulation of prostaglandin synthesis during differentiation of cultured mouse myeloid leukemia cellsJournal of Cellular Physiology, 1980
- Induction of differentiation of cultured human promyelocytic leukemia cells by retinoidsBiochemical and Biophysical Research Communications, 1980
- Clonal extinction of myelomonocytic leukemic cells by serum from mice injected with endotoxinInternational Journal of Cancer, 1980
- Regulation of macrophage and granulocyte proliferation. Specificities of prostaglandin E and lactoferrinThe Journal of Experimental Medicine, 1979
- Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide.The Journal of Experimental Medicine, 1979
- Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemiaNature, 1978
- Preparation of lymphocyte-activating factor from continuous murine macrophage cell linesCellular Immunology, 1977
- Continuous growth and differentiation of human myeloid leukaemic cells in suspension cultureNature, 1977
- Differentiation of a cell line of myeloid leukemiaJournal of Cellular Physiology, 1969