The Accumulation of Mono‐2‐Ethylhexylphthalate (MEHP) During Storage of Whole Blood and Plasma
- 10 September 1978
- journal article
- research article
- Published by Wiley in Transfusion
- Vol. 18 (5), 553-558
- https://doi.org/10.1046/j.1537-2995.1978.18579036383.x
Abstract
The accumulation of the plasticizer di-2-ethylhexylphthalate (DEHP) in blood and blood components has been of considerable [toxicity] concern for some time. The accumulation of DEHP and one of its major metabolites, MEHP was studied during storage of whole blood, platelet-rich palsma, platelet concentrates and platelet-poor plasma for periods from 72 h to 4 wk. Both phthalates showed a progressive increase in concentration with time. While the levels of DEHP were much greater than those of MEHP, there was nonetheless a significant and continual increase in MEHP in all preparations. The highest concentrations of DEHP and MEHP were in the platelet-poor plasma, indicating that platelets do not have a major role in the accumulation of MEHP was a direct result of the metabolism of DEHP by plasma protein(s) rather than leaching from the blood bag.This publication has 11 references indexed in Scilit:
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