METABOLISM AND EXCRETION OF DI(p‐AMINOPHENYL) SULPHOXIDE IN DIFFERENT ANIMAL SPECIES
Open Access
- 1 March 1960
- journal article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 15 (1), 160-164
- https://doi.org/10.1111/j.1476-5381.1960.tb01225.x
Abstract
Rabbits, rats and guinea-pigs were treated with di(p-aminophenyl) sulphoxide and their urines examined by an analytical method which permits the simultaneous determination of this compound and of sdapsone [di(p-aminophenyl) sulphone] which is a possible product of metabolic oxidation. The method gives for each drug the total of free compound plus acid-labile conjugates. All three species excreted unchanged drug together with dapsone. With rats and guinea-pigs about 33% of the excretion is dapsone, but with rabbits only 6 to 12%. The rate of combined excretion is much greater in rabbits than in the other two species. These results are discussed in relation to the significance of di(p-aminophenyl) sulphoxide as a drug in the treatment of leprosy.Keywords
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