EFFECTS OF INJECTIONS OF ACID AND TRAUMA ON JEJUNAL TRANSPLANTS TO THE STOMACH

Abstract

Experimental data are presented on further studies on intestinal segments transplanted to the stomach. Particular study has been made of the influences of the chemical and traumatic factors in the etiology of ulcer. The almost constant observation of hydrochloric acid in clinical peptic ulcer has frequently led to the conclusion that it is an essential element in its production. Experimentally, however, it has been rather definitely established by many workers that uninjured intestinal mucosa is unaffected by exposure to the digestive action of gastric juice. Isolated segments of intestine, with their blood supply intact, transplanted to the stomachs of dogs, remained unchanged in the experiments of Hotz¹ and Licini.² Later, Dragstedt and Vaughn³ showed that various parts of the intestinal tract, kidney and spleen transplanted to the stomach remained normal when subjected to the digestive action of gastric juice for long periods. In an experimental study of