High performance liquid chromatography of natural products. II. Direct biological correlation of components in the fermentation broth.
- 1 January 1978
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 31 (11), 1132-1136
- https://doi.org/10.7164/antibiotics.31.1132
Abstract
A portion of the eluent, during liquid chromatography of a fermentation broth, is applied directly to a paper strip at the same rate as the recording of the UV absorption. The paper is then placed on the agar inoculated with an appropriate test organism. This procedure permits direct correlation of [antibiotic] biological activity with corresponding peaks in the UV.This publication has 2 references indexed in Scilit:
- High performance liquid chromatography of natural products. I. Separation of cephalosporin C derivatives and cephalosporin antibiotics; isolation of cephalosporin C from fermentation broth.The Journal of Antibiotics, 1976
- Nocardicin a, a new monocyclic .BETA.-lactam antibiotic. I. Discovery, isolation and characterization.The Journal of Antibiotics, 1976