Specificity of acquired clonal chromosome abnormalities in new zealand black mice
- 15 April 1978
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 21 (4), 505-510
- https://doi.org/10.1002/ijc.2910210417
Abstract
New Zealand Black (NZB) mice, an inbred strain characterized by immunological dysfunction and lymphoreticular malignancy, also develop populations of aneuploid spleen cells. In detailed cytogenetic analyses performed on 10 NZBs, the chromosomally abnormal cells were found to be clonally related within each mouse. Moreover, the karyotypic changes observed were highly non-random, usually involving the 15 (10/10 mice), 2 (8/10 mice), 16 or 17 (9/10 mice), and sex (6/10 mice) chromosomes. These observations suggest an important relationship between chromosomal alterations and tumorigenesis in NZB mice and emphasize the role of chromosome 15 in murine abnormal lymphoreticular proliferations.Keywords
This publication has 9 references indexed in Scilit:
- Chromosome mapping of the genes that control differentiation and malignancy in myeloid leukemic cells.Proceedings of the National Academy of Sciences, 1977
- Expression of human and suppression of mouse nucleolus organizer activity in mouse-human somatic cell hybrids.Proceedings of the National Academy of Sciences, 1976
- Trisomy of chromosome 15 in spontaneous leukemia of AKR mice.Proceedings of the National Academy of Sciences, 1975
- Nonrandom chromosomal abnormalities in hematologic disorders of man.Proceedings of the National Academy of Sciences, 1975
- Chromosomal Abnormalities in Spleens of New Zealand Black Mice, A Strain Characterized by Autoimmunity and MalignancyProceedings of the National Academy of Sciences, 1973
- Karyotypic, Virologic, and Immunologic Analyses of Two Continuous Lymphocyte Lines Established from New Zealand Black Mice: Possible Relationship of Chromosomal Mosaicism to AutoimmunityProceedings of the National Academy of Sciences, 1972
- Possible Autoimmune Processes related to Chromosomal Abnormalities (Breakage) in NZB MiceNature New Biology, 1972
- A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMESThe Lancet, 1971
- Hypothesis: "Immunologic" OncogenesisBlood, 1967