The breakdown of ribonucleic acid in the cell nucleus
- 16 July 1963
- journal article
- research article
- Published by The Royal Society in Proceedings of the Royal Society of London. B. Biological Sciences
- Vol. 158 (970), 79-87
- https://doi.org/10.1098/rspb.1963.0035
Abstract
The enzyme responsible for the breakdown of the rapidly labelled ribonucleic acid (RNA) in the He La cell nucleus has the properties of a polynucleotide phosphorylase. This enzyme acts preferentially on the rapidly labelled RNA and appears to degrade it to nucleoside-5[image] diphosphates. Both the rapidly labelled RNA and the enzyme which degrades it are apparently attached to the chromosome.Keywords
This publication has 13 references indexed in Scilit:
- The isolation of nuclei from animal cells in cultureProceedings of the Royal Society of London. B. Biological Sciences, 1962
- Actinomycin D Inhibition of Deoxyribonucleic Acid-Dependent Synthesis of Ribonucleic AcidScience, 1962
- On the inhibition of RNA synthesis by actinomycinBiochemical and Biophysical Research Communications, 1962
- Protamine enhancement of RNA uptake by cultured chick cellsBiochemical and Biophysical Research Communications, 1961
- Biochemistry of Heredity: A General HypothesisNature, 1961
- Turnover of nuclear and cytoplasmic ribonucleic acid in two types of animal cell, with some further observations on the nucleolusBiochemical Journal, 1959
- Inhibition and Activation of Polynucleotide Phosphorylase through the Formation of Complexes between Acridine Orange and PolynucleotidesNature, 1958
- POLYNUCLEOTIDE PHOSPHORYLASE IN LIVER NUCLEIJournal of the American Chemical Society, 1957
- REVERSIBLE SYNTHESIS OF POLYRIBONUCLEOTIDES WITH AN ENZYME FROM ESCHERICHIA COLIJournal of Biological Chemistry, 1957
- Enzymic synthesis of polynucleotides I. polynucleotide phosphorylase of Azotobacter vinelandiiBiochimica et Biophysica Acta, 1956